Latest research shows a link between fructose, inflammation and breast cancer.
I continue to believe in the nutritional model of inflammation and its relationship with cancer, both in the development and creating treatment choices. I lecture on the macronutrient role of fructose, refined carbohydrates and polyunsaturated oils combining to create the inflammation that drives the process as well as impeding the body’s own ‘clean… up’ mechanisms.
This latest research adds in a piece of the jigsaw puzzle and the link between sugar, fructose and now breast cancer.
“We found that sucrose intake in mice comparable with levels of Western diets led to increased tumor growth and metastasis, when compared with a non-sugar starch diet.”
“We determined that fructose derived from the sucrose was responsible for facilitating lung metastasis and 12-HETE production in breast tumors. Overall, our data suggested that dietary sugar induces 12-LOX signaling to increase risks of breast cancer development and metastasis.”
“”We found that sucrose intake in mice comparable to levels of Western diets led to increased tumor growth and metastasis, when compared to a non-sugar starch diet,” said Peiying Yang, Ph.D.”
“”The current study investigated the impact of dietary sugar on mammary gland tumor development in multiple mouse models, along with mechanisms that may be involved,” said co-author Lorenzo Cohen, Ph.D., professor of Palliative, Rehabilitation, and Integrative Medicine. “We determined that it was specifically fructose, in table sugar and high-fructose corn syrup, ubiquitous within our food system, which was responsible for facilitating lung metastasis and 12-HETE production in breast tumors.””
“”Prior research has examined the role of sugar, especially glucose, and energy-based metabolic pathways in cancer development,” said Yang. “However, the inflammatory cascade may be an alternative route of studying sugar-driven carcinogenesis that warrants further study.”
No previous studies have investigated the direct effect of sugar consumption on the development of breast cancer using breast cancer animal models or examined specific mechanisms, she added.”
My Nutritional Model of Modern Disease/Inflammation and the Metabolic Model of Cancer is at
It’s about time that the cancer groups caring for patients take note and let patients know that there are options in management.
Lowering sugar and carbohydrate, cutting back on polyunsaturated oils – a LCHF lifestyle is a safe option to add in to conventional treatments of surgery, radiotherapy and chemotherapy.